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Microplastic-Induced Multi-Organ Toxicity: Cellular Mechanisms and Critical Roles of Organ Crosstalk

Key Finding

Oxidative stress, inflammation, mitochondrial dysfunction and programmed cell death recur across organs, and organ crosstalk amplifies harm. Parental exposure may also cause transgenerational effects in offspring.

Summary

A February 2026 review in Frontiers in Public Health on how microplastics accumulate in the liver, brain, lungs, kidneys, intestines, heart and reproductive organs. It focuses on how communication between organs, such as the gut-liver and gut-brain axes, amplifies damage.

PUBLISHED IN

Frontiers in Public Health

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Frontiers in Public Health

Frontiers in Public Health, 2026, vol 14 (DOI 10.3389/fpubh.2026.1746924)

February 3, 2026